Shaughna Phillips responds to Ozempic controversy with a strong six-word statement following her impressive six-stone weight loss

During the summer, I had the opportunity to attend a 60th birthday celebration where the post-dinner show featured a special performance by a renowned male pop star from the UK. What caught everyone’s attention even more than his performance was the amazing transformation the star had undergone. He appeared much slimmer than before, confidently dancing on stage in a striking silver outfit. His secret to this remarkable change? A new diet medication known as Semaglutide, branded as Ozempic, which seems to be the current craze among many, including a famous supermodel.

Initially created to address type 2 diabetes, Semaglutide is being utilized off-label in the US and the UK as a treatment for obesity. According to studies conducted by its manufacturer, Novo Nordisk, a pharmaceutical company based in Denmark, patients experienced an average weight loss of 17% of their total body weight over a 68-week period. This is significantly higher than the 5 to 9% weight loss typically seen with traditional anti-obesity drugs like Metformin.

While Ozempic is only prescribed by the NHS in the UK for individuals with type 2 diabetes, it can be acquired through a private physician. For those willing to use it without proper medical supervision – a practice strongly discouraged by healthcare providers (refer to panel) – the drug can be purchased online through various weight management programs. It is primarily administered through injections, although there are instances where it is taken in tablet form.

Originally developed to treat type 2 diabetes, Semaglutide is used off-label. It has been branded as a new diet drug that everybody is apparently taking

Predictably, Hollywood has been aware of Ozempic for a lot longer than us – Variety magazine recently quipped that the drug deserved its own thank-you speech at the Emmys, as so many stars on the podium had obviously been taking it. Elon Musk raved about its more powerful sister drug, Wegovy, on Twitter; Kim Kardashian, it is hotly rumoured, used semaglutide to lose 16lb in order to fit into Marilyn Monroe’s dress for the Met Ball. On TikTok the hashtag #ozempic has had more than 285 million views. 

Thanks to the hype, there has been a surge in demand, causing shortages on both sides of the Atlantic, with a backlash against influencers and celebrities hogging supplies ahead of desperate diabetes sufferers. Predictably, Big Pharma has come up with an alternative – tirzepatide (brand name Mounjaro), manufactured by Eli Lilly – but it has yet to be approved by the US Food & Drug Administration for weight loss. 

Novo Nordisk has issued a statement to say its supplies will be replenished by the end of the year, but it hasn’t quelled anxiety. At least two middle-aged male friends of mine who started using it in September are getting themselves in a twist about being caught short before the holidays. As one private London GP remarked to me: ‘It’s like the H RT panic last spring.’ 

So what exactly is this drug? Semaglutide belongs to a class called GLP-1 agonists, which not only regulate blood sugar but, as was discovered about a decade ago, also mimic the gut hormones that regulate our appetites – the ones that tell the brain when we are hungry or full. There are, of course, side effects: acid reflux, nausea, exacerbation of IBS symptoms and fatigue (but much less so than in earlier GLP-1 agonists such as Saxenda), as well as pancreatitis, gallstones and, in very high doses, it has caused thyroid tumours in rats. Meanwhile, when you stop using it the effect wears off immediately and in some cases it won’t work at all. 

‘I would describe semaglutide as an example of very smart science,’ says leading consultant endocrinologist Dr Efthimia Karra from her private practice off London’s Harley Street. ‘But it is not a panacea for everyone. Around a fifth of users do not respond to it. This is because the human body favours weight gain, thus when you lose weight the body will do anything to revert to its highest BMI. The heavier you are the harder it is to lose weight. If a patient has made no progress in three months, I will take them off it.’ 

Banker’s wife Laura, a native New Yorker in her mid-50s who had hovered between decades, started using it in January. ‘The Paleo diet, 5:2, CBT, NLP, bootcamp, diet delivery services – I’ve tried them all,’ she says from the family home in Hampshire, ‘and I’ve always yo-yoed right back. After my last annual checkup I seriously contemplated giving up. Then my doctor suggested semaglutide.’ 

After only a month she noticed her clothes had become looser. From then on, the weight started dropping off. ‘The strange thing was, I wasn’t eating anything different. I just couldn’t physically have seconds any more, and the idea of pudding after a full meal had lost its allure.’ Three months on, she is two stone lighter ‒ though occasionally she suffers heartburn if she eats too late at night or drinks alcohol ‒ and when we spoke in autumn, she was looking forward to losing another stone by Christmas. 

‘There is a niggling voice that tells me it is both risky and lazy to take a drug to lose weight, and I worry that it will all pile on again if I stop taking it. But if it does, I will seriously consider taking it indefinitely.’ 

Private London GP Dr Martin Galy has been prescribing semaglutide for about a year to clients who cannot lose the weight they gained in menopause. He has seen it have a transformational effect, too, on much younger women who suffer polycystic ovary syndrome. ‘PCOS sufferers are difficult to treat, and you can imagine how body image plays a very important part when it comes to self-esteem.’ 

But according to Tom Sanders, professor of nutrition and dietetics at King’s College London, it is not a magic bullet. Commenting on a study on semaglutide published in The New England Journal of Medicine in 2021, he says, ‘The challenge post-weight loss is to prevent a regain in weight,’ he wrote. It may prove to be useful in the short term, but ‘public health measures that encourage behavioural changes such as regular physical activity and moderating dietary energy intake are still needed’. 

That said, given our rising national obesity statistics and the escalation in accompanying health issues such as heart failure, cancer and obstructive sleep apnoea clogging up hospital beds, we’re going to need something. Semaglutide may be the rich person’s drug today, but might it be approved for more widespread use? Only time will tell.