"It's time." Ellen Pompeo tackles her first major role since 'Grey's Anatomy'

Ellen Pompeo, known for her role in “Grey’s Anatomy,” is shifting gears and venturing into new territories with her upcoming project, “Good American Family.” This marks her first endeavor after dedicating two decades to Grey’s Anatomy.

During the premiere of the show in Hollywood, Pompeo shared that she was attracted to this project because it offered a stark contrast to her long-standing role. She felt it was the right time for a change and embraced the opportunity wholeheartedly.

“Good American Family” stars Pomeo, Mark Duplass, Imogen Faith Reid, Dulé Hill, Christina Hendricks and Sarayu Blue.

The series draws inspiration from the intriguing real-life tale of Natalia Grace, a young Ukrainian girl with a rare form of Dwarfism who gets adopted by a family in the Midwest. However, things take a dark turn when the adoptive parents start suspecting that Natalia might not be a child as she claims but an adult deceiving them. This suspicion leads to legal involvement, bringing a new family into the mix, and unraveling a complex web of drama that blurs the lines between good and bad.

According to Pompeo, who stars as Kristine and is also an executive producer, the questions are by design.

“It’s the idea of perspective and the perspective shifting. We can all hear the same story and we can all come away with something different and I think that’s the interesting thing about being a human being,” said Pompeo.

Tackling a controversial story like Natalia Grace’s was particularly challenging for girl-dad Duplass.

“There’s that expression where once you become a parent, you become a parent to every child in the world. And I have real strong paternal energy and I have a little bit of savior complex energy which also helped me tap into Michael,” Duplass explained. “But in particular, the way that a father might treat his daughter, some of that stuff was really hard. And Imogen and I got really close, she plays Natalia. So it was very hard to do some of that stuff on set.”

For Reid, having veteran actors like Pompeo and Duplass as on-screen parents to help her through the nerves of her first role was a blessing.

“(Ellen) always told me that I can stand up for myself and have a voice and that was what I needed because this is my first big role and as a young woman, we always need to hear that,” Reid said. “And Mark, what an amazing human, like I have never seen a nicer human in my life.”

Hendricks plays Cynthia, a woman who comes into Natalia’s life after she is seemingly abandoned by her family.

“There’s sort of little clues to people’s personalities and sort of how people manipulate and how people gain power. I think a lot of this has to do with who has the power and who doesn’t and how you get that and who listens to who,” she said.

Hill plays Detective Drysdale, who is looking into allegations on all sides of this story.

“The main thing really was how it stays with you, something’s nagging you, you have to keep going back to it,” he said. “WIth Drysdale, he just could not let it go.”

“It was a very difficult story to be a part of and I feel deeply thankful for the really loving and supportive environment that we had and the cast that we have, this star of Imogen and Ellen and Mark and the showrunners,” said Sarayu Blue, who plays Kristine’s friend Valika. “There was a real creative collaboration every step of the way and that’s why it is what it is.”

The first two episodes of “Good American Family” premiere March 19 on Hulu. A new episode will drop weekly after that.

The Walt Disney Company is the parent company of Hulu and this ABC station.

Copyright © 2025 OnTheRedCarpet.com. All Rights Reserved.

You May Also Like
Columbine victim's 2025 death ruled a homicide after injuries from school shooting contributed to sepsis

“Columbine Victim’s 2025 Death Declared a Homicide Due to Sepsis Linked to School Shooting Injuries”

A woman who was partially paralyzed during the 1999 mass shooting at…
ICE Boston arrests Guatemalan national charged with child rape who was released back into community by court

Boston ICE detains Guatemalan citizen accused of child rape after being released by court

An accused child rapist illegally in the U.S. was recently arrested by…
A SEPTA positive vibes trolley spreads affirming messages to its riders

A trolley from SEPTA shares positive messages to uplift its passengers.

Philadelphia, Pennsylvania — If you’ve ever taken the Route 36 trolley through…
‘Adolescence’ Episode 1 Recap: My Son, My Son, What Have Ye Done?

Recap of Episode 1 of ‘Adolescence’: My Son, My Son, What Have You Done?

There was a comment online implying that by removing the jungle footage…
'Bourbon Street Hustler,' arrested after Kansas City reporter death, needs resentencing for fraud history: AG

‘Bourbon Street Con Artist,’ who was previously arrested for the death of a Kansas City journalist, must now face a new sentence due to their past fraudulent activities: Attorney General.

Louisiana’s attorney general is asking for a tougher sentence for a woman’s…
DHS agents search two students' rooms at Columbia University, leaving interim president 'heartbroken'

DHS agents search the rooms of two students at Columbia University, causing sadness to the interim president

Homeland Security agents recently conducted searches in the rooms of two students…
17-vehicle crash in Austin, Texas leaves 3 adults, 2 kids dead

Tragic Accident in Austin, Texas Claims Lives of 3 Adults and 2 Children

A 17-vehicle crash in Austin, Texas, left five people dead, including a…
USPS agrees to work with DOGE on reform, planning to cut 10,000 workers

USPS to collaborate with DOGE on restructuring, aiming to reduce workforce by 10,000

WASHINGTON — Postmaster General Louis DeJoy is set to reduce the U.S.…
Trump to visit the Justice Department, months after his criminal prosecutions were dismissed

Trump to visit Justice Department after his criminal prosecutions were dropped

President Donald Trump will be visiting the Justice Department to garner support…
SC Rep. Nancy Mace Accused a Man of Sexual Abuse in House Floor Speech. Now, He Is Suing for Defamation.

SC Rep. Nancy Mace Faces Defamation Lawsuit After Accusing Man of Sexual Abuse on House Floor

Rep. Nancy Mace (R-SC) is being sued by one of the men she…
How Prince Harry's become Spare to Meghan Markle's relentless ambitions: There's no sign of him in the Duchess's podcast or second series of Netflix show

Prince Harry: Supportive Husband Steps Back as Meghan Markle Takes Center Stage in Podcast and Netflix Series

She may have her critics – but even they would surely acknowledge…
Israel faces new Syria challenge as it adjusts to new strategy amid regional power struggle for influence

Israel confronts fresh challenge in Syria while adapting to new tactics during struggle for regional power dynamics.

In Tel Aviv, the Israeli Air Force conducted a strike on the…