In making his argument, Oscar Isaac points out how Dune is a bit more unique in its nature, despite featuring giant space ships like George Lucas’ franchise. Isaac makes a good point in mentioning that the author of Dune, Frank Herbert, was ahead of his time and, in like the late author, Denis Villeneuve has proven to be one of the most unique voices in the creative sphere. All in all, it sounds like the actor is saying there is much more going on in Dune, thematically, than Star Wars‘ typical “good guys fight bad guys” in space approach.
Source: Cinema Blend